Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12799401 | 0.95 | LMNA (0.91) | LMNAMAPTKDM4EALDH1A1ALOX15 | |
| SCHEMBL2895027 | 0.79 | KDM4E (1.00) | LMNAMAPTKDM4EALDH1A1ALOX15 | |
| SCHEMBL30688971 | 0.79 | KDM4E (1.00) | LMNAMAPTKDM4EALDH1A1ALOX15 | |
| SCHEMBL25012400 | 0.79 | LMNA (0.65) | LMNAMAPTKDM4EALDH1A1ALOX15 | |
| Hydrochloric Acid SCHEMBL28652496 | 0.78 | KDM4E (0.97) | LMNAMAPTKDM4EALDH1A1ALOX15 | |
| SCHEMBL5121168 | 0.78 | LMNA (0.63) | LMNAMAPTKDM4EALDH1A1ALOX15 | |
| SCHEMBL14543343 | 0.77 | LMNA (0.62) | LMNAMAPTKDM4EALDH1A1ALOX15 | |
| SCHEMBL25012395 | 0.77 | LMNA (0.62) | LMNAMAPTKDM4EALDH1A1ALOX15 | |
| SCHEMBL14276930 | 0.73 | LMNA (0.68) | LMNAMAPTKDM4EALDH1A1ALOX15 | |
| SCHEMBL25011226 | 0.72 | LMNA (0.55) | LMNAMAPTKDM4EALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708101-B1 | Piperidine derivatives, useful as neurokinin receptor antagonists | ADIR (FR) | 1998-12-09 | — | — | EP | disclosed |
| US-5652246-A | NEUROKININ RECEPTOR ANTAGONISTS; NERVOUS SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1997-07-29 | — | — | US | disclosed |
| EP-0708101-A1 | Novel piperidine derivatives, useful as neurokinin receptor antagonists | ADIR ET COMPAGNIE (FR) | 1996-04-24 | — | — | EP | disclosed |