Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 2/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | REN | P00797 | 3/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | KLK7 | P49862 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8564368 | 1.00 | PPARA (0.46) | PPARAKLK5PPARGCTSSSYK | |
| SCHEMBL7435516 | 0.82 | KLK5 (0.60) | KLK5CTSSRENCTSDTSHR | |
| SCHEMBL7638374 | 0.82 | KLK5 (0.60) | KLK5CTSSRENCTSDTSHR | |
| SCHEMBL8570488 | 0.81 | PPARA (0.49) | PPARAKLK5PPARGCTSSSYK | |
| SCHEMBL8570491 | 0.81 | PPARA (0.49) | PPARAKLK5PPARGCTSSSYK | |
| SCHEMBL8562719 | 0.80 | PPARA (0.49) | PPARAKLK5PPARGCTSSREN | |
| SCHEMBL8562726 | 0.80 | PPARA (0.49) | PPARAKLK5PPARGCTSSREN | |
| SCHEMBL7638338 | 0.79 | PTPN1 (0.52) | KLK5RENCTSDTSHRPSEN1 | |
| SCHEMBL7638333 | 0.79 | PTPN1 (0.52) | KLK5RENCTSDTSHRPSEN1 | |
| SCHEMBL8564212 | 0.78 | PPARA (0.45) | PPARAKLK5PPARGCTSSREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |