Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | REN | P00797 | 3/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8564217 | 1.00 | PPARA (0.45) | PPARAKLK5PSEN1PSEN2APH1B | |
| SCHEMBL8570488 | 0.83 | PPARA (0.49) | PPARAKLK5PSEN1PSEN2APH1B | |
| SCHEMBL8562726 | 0.83 | PPARA (0.49) | PPARAKLK5PSEN1PSEN2APH1B | |
| SCHEMBL8562719 | 0.83 | PPARA (0.49) | PPARAKLK5PSEN1PSEN2APH1B | |
| SCHEMBL8570491 | 0.83 | PPARA (0.49) | PPARAKLK5PSEN1PSEN2APH1B | |
| SCHEMBL8568098 | 0.81 | PPARA (0.46) | PPARAKLK5PSEN1PSEN2APH1B | |
| SCHEMBL8565474 | 0.79 | CA1 (0.38) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8565477 | 0.79 | CA1 (0.38) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8564364 | 0.78 | PPARA (0.46) | PPARAKLK5PSEN1PSEN2APH1B | |
| SCHEMBL8564368 | 0.78 | PPARA (0.46) | PPARAKLK5PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |