SCHEMBL8564403

SCHEMBL8564403

COC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 3/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8560851 0.91 BDKRB2 (0.81) BDKRB2
SCHEMBL8567481 0.91 BDKRB2 (0.72) BDKRB2
SCHEMBL8564263 0.90 BDKRB2 (0.83) BDKRB2
SCHEMBL8560167 0.90 BDKRB2 (0.77) BDKRB2
Hydrochloric Acid SCHEMBL8566083 0.90 BDKRB2 (0.81) BDKRB2
SCHEMBL8569532 0.89 BDKRB2 (0.81) BDKRB2
SCHEMBL8561464 0.89 BDKRB2 (0.81) BDKRB2
SCHEMBL8568509 0.89 BDKRB2 (0.89) BDKRB2
SCHEMBL8562676 0.89 BDKRB2 (0.72) BDKRB2
SCHEMBL8565452 0.89 BDKRB2 (0.72) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0596406-B1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO (JP) 1998-12-16 EP disclosed
EP-0596406-A1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-05-11 EP disclosed