Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 9/20 | 0.65 |
| ▸ | LTB4R2 | Q9NPC1 | 9/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8418922 | 0.94 | LTB4R (0.57) | LTB4RLTB4R2ALDH1A1POLBMAPT | |
| SCHEMBL8418885 | 0.88 | LTB4R (0.65) | LTB4RLTB4R2ALDH1A1POLBMAPT | |
| SCHEMBL8418430 | 0.86 | LTB4R (0.52) | LTB4RLTB4R2ALDH1A1POLBMAPT | |
| SCHEMBL8420802 | 0.85 | LTB4R (0.46) | LTB4RLTB4R2ALDH1A1POLBMAPT | |
| SCHEMBL8418438 | 0.84 | LTB4R (0.54) | LTB4RLTB4R2ALDH1A1POLBMAPT | |
| SCHEMBL8600595 | 0.83 | LTB4R (0.46) | LTB4RLTB4R2ALDH1A1POLBAPP | |
| SCHEMBL8569978 | 0.82 | LTB4R (0.52) | LTB4RLTB4R2ALDH1A1POLBMAPT | |
| SCHEMBL8420169 | 0.82 | LTB4R (0.52) | LTB4RLTB4R2ALDH1A1POLBMAPT | |
| SCHEMBL8571699 | 0.82 | LTB4R (0.52) | LTB4RLTB4R2ALDH1A1POLBMAPT | |
| SCHEMBL8422165 | 0.82 | LTB4R (0.46) | LTB4RLTB4R2ALDH1A1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942903-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | Novartis AG (CH) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998013347-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | NOVARTIS AG (CH) | 1998-04-02 | — | — | WO | disclosed |