Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.76 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.76 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | BUB1 | O43683 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | APOB | P04114 | 1/20 | 0.37 |
| ▸ | MTTP | P55157 | 1/20 | 0.37 |
| ▸ | CCKBR | P32239 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8564595 | 1.00 | MTNR1A (0.76) | MTNR1AMTNR1BEPHX2MAPK1BUB1 | |
| SCHEMBL8564600 | 1.00 | MTNR1A (0.76) | MTNR1AMTNR1BEPHX2MAPK1BUB1 | |
| SCHEMBL27057753 | 0.88 | MTNR1A (0.70) | MTNR1AMTNR1BEPHX2MAPK1DRD2 | |
| SCHEMBL19322908 | 0.86 | MTNR1A (1.00) | MTNR1AMTNR1BEPHX2GAAMAPT | |
| SCHEMBL25330881 | 0.85 | MTNR1A (0.77) | MTNR1AMTNR1BEPHX2MAPK1MEN1 | |
| SCHEMBL19318516 | 0.84 | MTNR1A (0.76) | MTNR1AMTNR1BEPHX2MAPK1DRD2 | |
| SCHEMBL7829223 | 0.84 | MTNR1A (0.64) | MTNR1AMTNR1BEPHX2MAPK1DRD2 | |
| SCHEMBL16181821 | 0.78 | MTNR1A (0.67) | MTNR1AMTNR1BEPHX2MEN1KMT2A | |
| SCHEMBL19319093 | 0.77 | MTNR1A (0.66) | MTNR1AMTNR1BEPHX2MAPK1DRD2 | |
| SCHEMBL8561743 | 0.76 | EPHX2 (0.78) | MTNR1AMTNR1BEPHX2MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0702004-A2 | 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amid derivatives | CIBA-GEIGY AG (CH) | 1996-03-20 | — | — | EP | disclosed |