Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 18/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.58 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8565542 | 0.88 | ALOX5AP (0.60) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL9291745 | 0.86 | ALOX5AP (0.65) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL9048306 | 0.84 | ALOX5AP (0.84) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL8565809 | 0.82 | ALOX5AP (0.65) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL9045553 | 0.81 | ALOX5AP (0.79) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL9291636 | 0.79 | ALOX5AP (0.61) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL2107903 | 0.77 | ALOX5AP (0.81) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL2108396 | 0.77 | ALOX5AP (0.83) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL2106671 | 0.77 | ALOX5AP (0.89) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL8559592 | 0.77 | ALOX5AP (0.72) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691972-B1 | FURO 3,2-b]PYRIDINES AND THIENO 3,2-b]PYRIDINES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC (CA) | 1998-07-01 | — | — | EP | disclosed |
| US-5374635-A | Antiinflammatory agents, lipoxygenase inhibitor, antiallergens , cytoprotective agents | MERCK FROSST CANADA, INC. (CA) | 1994-12-20 | — | — | US | disclosed |