Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 18/20 | 0.84 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.81 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.81 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.78 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.78 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2107903 | 0.93 | ALOX5AP (0.81) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL2108396 | 0.93 | ALOX5AP (0.83) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL8559592 | 0.92 | ALOX5AP (0.72) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL2108478 | 0.91 | ALOX5AP (1.00) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL2108514 | 0.90 | ALOX5AP (0.85) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL2108178 | 0.89 | PTGS1 (1.00) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL2107877 | 0.89 | PTGS1 (0.86) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL3103085 | 0.89 | ALOX5AP (0.69) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL4594756 | 0.89 | ALOX5AP (0.76) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL2108907 | 0.89 | PTGS1 (0.87) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0535925-B1 | (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC (CA) | 1996-04-24 | — | — | EP | disclosed |
| US-5308850-A | (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1994-05-03 | — | — | US | disclosed |
| EP-0535925-A1 | (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1993-04-07 | — | — | EP | disclosed |