Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 1/20 | 0.45 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 3/20 | 0.43 |
| ▸ | MMP14 | P50281 | 3/20 | 0.43 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 3/20 | 0.40 |
| ▸ | CTSK | P43235 | 4/20 | 0.40 |
| ▸ | CTSL | P07711 | 2/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | MMP3 | P08254 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8131433 | 0.86 | PTAFR (0.57) | PTAFRADAMTS5MMP13MMP9MMP1 | |
| SCHEMBL8581562 | 0.84 | PTAFR (0.48) | PTAFRADAMTS5ADAMTS4MMP13MMP3 | |
| SCHEMBL8561448 | 0.82 | PTAFR (0.45) | PTAFRADAMTS5ADAMTS4MMP13MMP3 | |
| SCHEMBL8584285 | 0.81 | PTAFR (0.42) | PTAFRADAMTS5MMP2MMP14ADAMTS4 | |
| SCHEMBL9595768 | 0.78 | PTAFR (0.53) | PTAFRADAMTS5ADAMTS4MMP1PLAU | |
| SCHEMBL9594827 | 0.77 | ATM (0.48) | PTAFRADAMTS5ADAMTS4MMP1PLAU | |
| SCHEMBL8565372 | 0.76 | PTAFR (0.41) | PTAFRADAMTS5MMP2MMP14ADAMTS4 | |
| SCHEMBL8123940 | 0.75 | PTAFR (0.83) | PTAFR | |
| SCHEMBL8123937 | 0.75 | PTAFR (0.42) | PTAFRADAMTS5MMP2MMP14ADAMTS4 | |
| SCHEMBL8135677 | 0.75 | PTAFR (0.44) | PTAFRADAMTS5MMP2MMP14ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0605434-B1 | IMIDAZO (4,5-C) PYRIDINE DERIVATIVES AS PAF ANTAGONISTS | BRITISH BIOTECH PHARM (GB) | 1998-08-19 | — | — | EP | disclosed |
| US-5446032-A | Platelet activsating factor antagonist | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1995-08-29 | — | — | US | disclosed |
| EP-0605434-A1 | IMIDAZO (4,5-C) PYRIDINE DERIVATIVES AS PAF ANTAGONISTS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1994-07-13 | — | — | EP | disclosed |
| WO-1993002080-A1 | IMIDAZO (4,5-C) PYRIDINE DERIVATIVES AS PAF ANTAGONISTS | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1993-02-04 | — | — | WO | disclosed |