Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | BMP1 | P13497 | 3/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 2/20 | 0.33 |
| ▸ | MMP13 | P45452 | 2/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8131433 | 0.86 | PTAFR (0.57) | PTAFRPLAUMMP1ALDH1A1HPGD | |
| SCHEMBL8581562 | 0.84 | PTAFR (0.48) | PTAFRPLAUMMP1ALDH1A1HPGD | |
| SCHEMBL8564824 | 0.82 | PTAFR (0.45) | PTAFRPLAUMMP1ADAMTS5MMP9 | |
| SCHEMBL8571542 | 0.81 | ALDH1A1 (0.39) | PTAFRMMP1ALDH1A1HPGDBMP1 | |
| SCHEMBL8563675 | 0.76 | MMP2 (0.47) | NPSR1PLAUMMP1ALDH1A1HPGD | |
| SCHEMBL8569264 | 0.76 | MMP2 (0.47) | NPSR1PLAUMMP1ALDH1A1HPGD | |
| SCHEMBL8563029 | 0.76 | PTAFR (0.41) | PTAFRPLAUALDH1A1HPGDBMP1 | |
| SCHEMBL8568591 | 0.76 | PTAFR (0.41) | PTAFRPLAUALDH1A1HPGDBMP1 | |
| SCHEMBL6722457 | 0.75 | LMNA (0.45) | MMP1MMP9MMP13ADAM17MMP3 | |
| SCHEMBL8584285 | 0.75 | PTAFR (0.42) | PTAFRPLAUMMP1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0605434-B1 | IMIDAZO (4,5-C) PYRIDINE DERIVATIVES AS PAF ANTAGONISTS | BRITISH BIOTECH PHARM (GB) | 1998-08-19 | — | — | EP | disclosed |
| US-5446032-A | Platelet activsating factor antagonist | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1995-08-29 | — | — | US | disclosed |
| EP-0605434-A1 | IMIDAZO (4,5-C) PYRIDINE DERIVATIVES AS PAF ANTAGONISTS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1994-07-13 | — | — | EP | disclosed |
| WO-1993002080-A1 | IMIDAZO (4,5-C) PYRIDINE DERIVATIVES AS PAF ANTAGONISTS | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1993-02-04 | — | — | WO | disclosed |