Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.53 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 2/20 | 0.48 |
| ▸ | CNR2 | P34972 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10545883 | 0.95 | CHRNB2 (0.54) | CHRNB2CHRNA4CNR1CNR2DRD2 | |
| SCHEMBL7089196 | 0.86 | CHRNB2 (0.67) | CHRNB2CHRNA4CNR1CNR2DRD2 | |
| SCHEMBL16902833 | 0.84 | CHRNB2 (0.65) | CHRNB2CHRNA4CNR1CNR2DRD2 | |
| SCHEMBL16902829 | 0.84 | CHRNB2 (0.65) | CHRNB2CHRNA4CNR1CNR2DRD2 | |
| SCHEMBL9009814 | 0.84 | CHRNB2 (0.65) | CHRNB2CHRNA4CNR1CNR2DRD2 | |
| SCHEMBL9126822 | 0.84 | CHRNB2 (0.65) | CHRNB2CHRNA4CNR1CNR2DRD2 | |
| SCHEMBL16902831 | 0.84 | CHRNB2 (0.65) | CHRNB2CHRNA4CNR1CNR2DRD2 | |
| SCHEMBL11243720 | 0.84 | CHRNB2 (0.65) | CHRNB2CHRNA4CNR1CNR2DRD2 | |
| SCHEMBL16902832 | 0.84 | CHRNB2 (0.65) | CHRNB2CHRNA4CNR1CNR2DRD2 | |
| SCHEMBL16902848 | 0.84 | CHRNB2 (0.65) | CHRNB2CHRNA4CNR1CNR2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544488-B1 | Substituted phenyl phenol leukotriene antagonists | LILLY CO ELI (US) | 1998-03-11 | — | — | EP | disclosed |
| CN-1035001-C | Substituted phenyl phenol leukotriene antagonists | LILLY CO ELI (US) | 1997-05-28 | — | — | CN | disclosed |
| WO-1996036347-A1 | USE OF LEUKOTRIENE ANTAGONISTS FOR ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1996-11-21 | — | — | WO | disclosed |
| EP-0743064-A1 | Leukotriene antagonists for use in the treatment or prevention of alzheimer's disease | ELI LILLY AND COMPANY (US) | 1996-11-20 | — | — | EP | disclosed |
| US-5462954-A | Antiinflammatory, antiallergens; treating asthma | ELI LILLY AND COMPANY (US) | 1995-10-31 | — | — | US | disclosed |
| CN-1088906-A | The phenyl phenol leukotriene antagonists that replaces | LILLY CO ELI (US) | 1994-07-06 | — | — | CN | disclosed |
| EP-0544488-A2 | Substituted phenyl phenol leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1993-06-02 | — | — | EP | disclosed |