SCHEMBL8565177

SCHEMBL8565177

CC(=O)N(C)c1ccc(Cl)c(COc2cccn3cc(C)nc23)c1

nearest known ligand 0.56

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 5/20 0.42
PPARG P37231 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8668353 0.90 BDKRB2 (0.42) BDKRB2PPARG
SCHEMBL8671408 0.89 GRM5 (0.43) BDKRB2PPARG
SCHEMBL8563624 0.87 BDKRB2 (0.41) BDKRB2
Hydrochloric Acid SCHEMBL8666495 0.86 BDKRB2 (0.42) BDKRB2
SCHEMBL8567070 0.83 BDKRB2 (0.59) BDKRB2
SCHEMBL8569323 0.82 BDKRB2 (0.56) BDKRB2
SCHEMBL8672788 0.81 BDKRB2 (0.45) BDKRB2
Hydrochloric Acid SCHEMBL8672888 0.81 BDKRB2 (0.56) BDKRB2
SCHEMBL8563526 0.80 BDKRB2 (0.44) BDKRB2
Hydrochloric Acid SCHEMBL8666531 0.80 BDKRB2 (0.46) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0596406-B1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO (JP) 1998-12-16 EP disclosed
US-5750699-A HALOGENATING OF CORRESPONDING COMPOUND FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-05-12 US disclosed
US-5574042-A ANTAGONIST FOR BRADYKININS AS ANTIALLERGENS, AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS, SHOCK OR PAIN FUJISAWA PHARMACEUTICAL CO., LTD (JP) 1996-11-12 US disclosed
EP-0596406-A1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-05-11 EP disclosed