Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 8/20 | 0.50 |
| ▸ | UTS2R | Q9UKP6 | 8/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8834703 | 1.00 | OPRK1 (0.50) | OPRK1UTS2RHRH3CYP3A4CYP2D6 | |
| SCHEMBL8567889 | 0.99 | OPRK1 (0.49) | OPRK1UTS2RHRH3 | |
| Hydrochloric Acid SCHEMBL8561472 | 0.99 | OPRK1 (0.49) | OPRK1UTS2RHRH3 | |
| SCHEMBL8560543 | 0.92 | OPRK1 (0.59) | OPRK1UTS2RHRH3 | |
| SCHEMBL8564004 | 0.91 | OPRK1 (0.58) | OPRK1UTS2RHRH3 | |
| SCHEMBL8558029 | 0.90 | OPRK1 (0.42) | OPRK1UTS2RHRH3 | |
| SCHEMBL8560554 | 0.90 | OPRK1 (0.42) | OPRK1UTS2RHRH3 | |
| Hydrochloric Acid SCHEMBL8563826 | 0.89 | OPRK1 (0.42) | OPRK1UTS2RHRH3 | |
| SCHEMBL8561543 | 0.88 | OPRK1 (0.40) | OPRK1UTS2RHRH3 | |
| SCHEMBL8834995 | 0.88 | OPRK1 (0.45) | OPRK1UTS2RHRH3CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756730-A | Process for preparing analgesic compounds | SANKYO COMPANY, LIMITED (JP) | 1998-05-26 | — | — | US | disclosed |
| US-5656758-A | AMIDATION OF AN AMINE-CONTAINING THIOMORPHOLINE OR PIPERAZINE COMPOUND | SANKYO COMPANY, LIMITED (JP) | 1997-08-12 | — | — | US | disclosed |
| US-5512567-A | KAPPA-RECEPTOR AGONISTS | SANKYO COMPANY, LIMITED (JP) | 1996-04-30 | — | — | US | disclosed |
| US-5270327-A | Piperidine derivatives | SANKYO COMPANY, LIMITED (JP) | 1993-12-14 | — | — | US | disclosed |
| EP-0356247-B1 | ANALGESIC CARBOXYLIC ACID AMIDE DERIVATIVES | Sankyo Company Limited (JP) | 1993-03-17 | — | — | EP | disclosed |
| US-5021413-A | Analgesic thiomorpholins their preparation, and pharmaceutical compositions containing them | SANKYO COMPANY LIMITED (JP) | 1991-06-04 | — | — | US | disclosed |
| EP-0356247-A1 | Analgesic carboxylic acid amide derivatives | Sankyo Company Limited (JP) | 1990-02-28 | — | — | EP | disclosed |