Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 19/20 | 0.47 |
| ▸ | LTB4R2 | Q9NPC1 | 18/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6902570 | 0.85 | LTB4R (0.52) | LTB4RLTB4R2NR1H4 | |
| SCHEMBL8561280 | 0.84 | LTB4R (0.51) | LTB4RLTB4R2NR1H4 | |
| SCHEMBL6756183 | 0.84 | LTB4R (0.48) | LTB4RLTB4R2 | |
| SCHEMBL6757535 | 0.83 | LTB4R (0.50) | LTB4RLTB4R2NR1H4 | |
| SCHEMBL8564707 | 0.79 | LTB4R (0.43) | LTB4RLTB4R2NR1H4 | |
| SCHEMBL6759039 | 0.79 | NR1H4 (0.51) | LTB4RLTB4R2NR1H4 | |
| SCHEMBL6757439 | 0.78 | NR1H4 (0.48) | LTB4RLTB4R2NR1H4 | |
| SCHEMBL8568443 | 0.78 | LTB4R (0.77) | LTB4RLTB4R2 | |
| SCHEMBL8566998 | 0.78 | LTB4R (0.56) | LTB4RLTB4R2 | |
| SCHEMBL6759116 | 0.78 | NR1H4 (0.47) | LTB4RLTB4R2NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544488-B1 | Substituted phenyl phenol leukotriene antagonists | LILLY CO ELI (US) | 1998-03-11 | — | — | EP | disclosed |
| WO-1996036347-A1 | USE OF LEUKOTRIENE ANTAGONISTS FOR ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1996-11-21 | — | — | WO | disclosed |
| EP-0743064-A1 | Leukotriene antagonists for use in the treatment or prevention of alzheimer's disease | ELI LILLY AND COMPANY (US) | 1996-11-20 | — | — | EP | disclosed |
| US-5462954-A | Antiinflammatory, antiallergens; treating asthma | ELI LILLY AND COMPANY (US) | 1995-10-31 | — | — | US | disclosed |
| EP-0544488-A2 | Substituted phenyl phenol leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1993-06-02 | — | — | EP | disclosed |