Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TOP2A | P11388 | 7/20 | 0.34 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | MATK | P42679 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7501604 | 0.99 | SCN5A (0.41) | SCN5AKCNH2ALDH1A1POLBCHRM2 | |
| SCHEMBL6170804 | 0.93 | SCN5A (0.39) | SCN5AKCNH2ALDH1A1POLBCHRM2 | |
| SCHEMBL6170904 | 0.93 | SCN5A (0.39) | SCN5AKCNH2ALDH1A1POLBCHRM2 | |
| Abt-719 SCHEMBL8569278 | 0.93 | ALDH1A1 (0.46) | SCN5AKCNH2ALDH1A1POLBCHRM2 | |
| Abt-719 SCHEMBL1290350 | 0.93 | ALDH1A1 (0.46) | SCN5AKCNH2ALDH1A1POLBCHRM2 | |
| Abt-719 SCHEMBL1290190 | 0.93 | ALDH1A1 (0.46) | SCN5AKCNH2ALDH1A1POLBCHRM2 | |
| Hydrochloric Acid SCHEMBL6475247 | 0.92 | SCN5A (0.38) | SCN5AKCNH2ALDH1A1POLBCHRM2 | |
| Abt-719 SCHEMBL7496844 | 0.92 | ALDH1A1 (0.45) | SCN5AKCNH2ALDH1A1POLBCHRM2 | |
| Abt-719 SCHEMBL7496841 | 0.92 | ALDH1A1 (0.45) | SCN5AKCNH2ALDH1A1POLBCHRM2 | |
| Abt-719 SCHEMBL7507152 | 0.92 | ALDH1A1 (0.45) | SCN5AKCNH2ALDH1A1POLBCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5599816-A | BACTERICIDE | ABBOTT LABORATORIES (US) | 1997-02-04 | — | — | US | claimed |
| WO-1996039407-A1 | QUINOLIZINONE TYPE COMPOUNDS | ABBOTT LABORATORIES (US) | 1996-12-12 | — | — | WO | claimed |
| EP-0871628-A1 | QUINOLIZINONE TYPE COMPOUNDS | Abbott Laboratories (US) | 1998-10-21 | — | — | EP | disclosed |
| US-5726182-A | TREATMENT OF BACTERIAL INFECTIONS | ABBOTT LABORATORIES (US) | 1998-03-10 | — | — | US | disclosed |
| US-5599816-A | BACTERICIDE | ABBOTT LABORATORIES (US) | 1997-02-04 | — | — | US | disclosed |
| WO-1996039407-A1 | QUINOLIZINONE TYPE COMPOUNDS | ABBOTT LABORATORIES (US) | 1996-12-12 | — | — | WO | disclosed |