SCHEMBL8565460

SCHEMBL8565460

Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(C(=O)Nc5ccncc5)c4)c3Cl)cccn2c1Cl

nearest known ligand 0.74

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 19/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8561943 0.99 BDKRB2 (0.74) BDKRB2
SCHEMBL8564203 0.94 BDKRB2 (0.84) BDKRB2
Hydrochloric Acid SCHEMBL8558946 0.93 BDKRB2 (0.84) BDKRB2
Hydrochloric Acid SCHEMBL8560592 0.88 BDKRB2 (0.86) BDKRB2
SCHEMBL8560857 0.87 BDKRB2 (0.74) BDKRB2
Hydrochloric Acid SCHEMBL8567777 0.87 BDKRB2 (0.74) BDKRB2
SCHEMBL8567117 0.86 BDKRB2 (0.89) BDKRB2
Hydrochloric Acid SCHEMBL8567951 0.85 BDKRB2 (0.89) BDKRB2
SCHEMBL8561594 0.85 BDKRB2 (1.00) BDKRB2
SCHEMBL7747429 0.84 BDKRB2 (0.82) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0596406-B1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO (JP) 1998-12-16 EP disclosed
US-5574042-A ANTAGONIST FOR BRADYKININS AS ANTIALLERGENS, AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS, SHOCK OR PAIN FUJISAWA PHARMACEUTICAL CO., LTD (JP) 1996-11-12 US disclosed
EP-0596406-A1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-05-11 EP disclosed