SCHEMBL8565532

SCHEMBL8565532

Nc1nc(Cl)cc(N2CCNCC2)n1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 4/20 0.72
CYP1A2 P05177 3/20 0.66
MAPT P10636 3/20 0.66
CYP2D6 P10635 2/20 0.66
HRH3 Q9Y5N1 3/20 0.57
KMT2A Q03164 3/20 0.56
ALDH1A1 P00352 2/20 0.51
HTR3E A5X5Y0 2/20 0.51
HTR3B O95264 2/20 0.51
HTR3A P46098 2/20 0.51
HTR3D Q70Z44 2/20 0.51
HTR3C Q8WXA8 2/20 0.51
MEN1 O00255 2/20 0.51
CYP3A4 P08684 2/20 0.51
CYP2C9 P11712 2/20 0.51
CYP2C19 P33261 2/20 0.51
KDM4E B2RXH2 1/20 0.51
HTR1A P08908 1/20 0.51
HPGD P15428 1/20 0.51
HTR2A P28223 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3719291 0.84 MAPT (0.72) HRH4CYP1A2MAPTCYP2D6HRH3
SCHEMBL1318180 0.84 MAPT (0.72) HRH4CYP1A2MAPTCYP2D6HRH3
SCHEMBL1318490 0.82 CYP1A2 (0.70) HRH4CYP1A2MAPTCYP2D6KMT2A
SCHEMBL1320033 0.82 CYP1A2 (0.70) HRH4CYP1A2MAPTCYP2D6KMT2A
SCHEMBL18153285 0.82 ALDH1A1 (0.54) HRH4CYP1A2MAPTCYP2D6HRH3
SCHEMBL655533 0.82 HRH4 (0.77) HRH4HRH3CASP1CASP4CASP5
SCHEMBL1617816 0.79 HRH4 (0.72) HRH4MAPTHRH3CASP1CASP4
SCHEMBL1028538 0.79 CYP1A2 (1.00) HRH4CYP1A2MAPTCYP2D6KMT2A
SCHEMBL20905447 0.79 KMT2A (0.51) HRH4CYP1A2MAPTCYP2D6KMT2A
SCHEMBL1024211 0.79 HRH4 (0.70) HRH4CYP1A2MAPTCYP2D6HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0644885-A1 NOVEL BIOLOGICALLY ACTIVE EBURNAMENINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME RICHETER GEDEON VEGYESZETI GYAR RT. (HU) 1995-03-29 EP claimed
WO-1993025550-A1 NOVEL BIOLOGICALLY ACTIVE EBURNAMENINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME RICHETER GEDEON VEGYÉSZETI GYÁR RT. (HU) 1993-12-23 WO claimed
WO-1998025617-A1 SUBSTITUTED ARYL PIPERAZINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 1998-06-18 WO disclosed
EP-0783498-A4 SUBSTITUTED ARYL PIPERAZINES AS NEUROKININ ANTAGONISTS MERCK & CO INC (US) 1998-04-15 EP disclosed
EP-0783498-A1 SUBSTITUTED ARYL PIPERAZINES AS NEUROKININ ANTAGONISTS MERCK & CO. INC. (US) 1997-07-16 EP disclosed
US-5607936-A USEFUL IN TREATMENT OF RESPIRATORY DISEASES MERCK & CO., INC. (US) 1997-03-04 US disclosed
WO-1996010568-A1 SUBSTITUTED ARYL PIPERAZINES AS NEUROKININ ANTAGONISTS MERCK & CO., INC. (US) 1996-04-11 WO disclosed
EP-0644885-A1 NOVEL BIOLOGICALLY ACTIVE EBURNAMENINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME RICHETER GEDEON VEGYESZETI GYAR RT. (HU) 1995-03-29 EP disclosed
WO-1993025550-A1 NOVEL BIOLOGICALLY ACTIVE EBURNAMENINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME RICHETER GEDEON VEGYÉSZETI GYÁR RT. (HU) 1993-12-23 WO disclosed
US-4535080-A HYPOTENSIVE AGENTS, ANTIGLYCEMIC AGENTS, ANTIMIGRAINE AGENTS AND ANTIDEPRESSANTS PHARMUKA LABORATOIRES (FR) 1985-08-13 US disclosed