SCHEMBL8565618

SCHEMBL8565618

COCCCNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cn1

nearest known ligand 0.84

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 20/20 0.84

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8565622 1.00 BDKRB2 (0.84) BDKRB2
Hydrochloric Acid SCHEMBL8568049 0.99 BDKRB2 (0.84) BDKRB2
Hydrochloric Acid SCHEMBL8568053 0.99 BDKRB2 (0.84) BDKRB2
SCHEMBL8559174 0.93 BDKRB2 (0.84) BDKRB2
SCHEMBL8559177 0.93 BDKRB2 (0.84) BDKRB2
Hydrochloric Acid SCHEMBL8566539 0.93 BDKRB2 (0.84) BDKRB2
Hydrochloric Acid SCHEMBL8566541 0.93 BDKRB2 (0.84) BDKRB2
SCHEMBL8566296 0.92 BDKRB2 (0.89) BDKRB2
SCHEMBL8566305 0.92 BDKRB2 (0.89) BDKRB2
Hydrochloric Acid SCHEMBL8559169 0.91 BDKRB2 (0.89) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0596406-B1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO (JP) 1998-12-16 EP disclosed
US-5574042-A ANTAGONIST FOR BRADYKININS AS ANTIALLERGENS, AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS, SHOCK OR PAIN FUJISAWA PHARMACEUTICAL CO., LTD (JP) 1996-11-12 US disclosed
EP-0596406-A1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-05-11 EP disclosed