Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8564562 | 0.94 | ALDH1A1 (0.49) | ALDH1A1MAPTSMN1; SMN2HPGDKDM4E | |
| SCHEMBL8567057 | 0.87 | ALDH1A1 (0.46) | ALDH1A1MAPTSMN1; SMN2HPGDKDM4E | |
| SCHEMBL8561759 | 0.85 | ALDH1A1 (0.51) | ALDH1A1MAPTSMN1; SMN2HPGDKDM4E | |
| SCHEMBL7984810 | 0.81 | ALDH1A1 (0.51) | ALDH1A1MAPTSMN1; SMN2HPGDKDM4E | |
| SCHEMBL6995967 | 0.81 | ALDH1A1 (0.52) | ALDH1A1MAPTSMN1; SMN2HPGDKDM4E | |
| Water SCHEMBL10396513 | 0.79 | KDM4E (0.52) | ALDH1A1MAPTSMN1; SMN2HPGDKDM4E | |
| Water SCHEMBL10396512 | 0.79 | KDM4E (0.52) | ALDH1A1MAPTSMN1; SMN2HPGDKDM4E | |
| SCHEMBL6999609 | 0.79 | KDM4E (0.52) | ALDH1A1MAPTSMN1; SMN2HPGDKDM4E | |
| SCHEMBL14173460 | 0.79 | ALDH1A1 (0.47) | ALDH1A1MAPTSMN1; SMN2HPGDKDM4E | |
| SCHEMBL7988314 | 0.79 | ALDH1A1 (0.48) | ALDH1A1MAPTSMN1; SMN2HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539421-B1 | NOVEL OXAZOLYL DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 1998-09-23 | — | — | EP | disclosed |
| US-5278165-A | Oxazolyl imidazol[4,5-b]pyridin and pyrimidine compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-01-11 | — | — | US | disclosed |
| US-5217980-A | Antiallergens | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-06-08 | — | — | US | disclosed |
| WO-1992001687-A1 | NOVEL OXAZOLYL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-02-06 | — | — | WO | disclosed |