Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 7/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.79 |
| ▸ | POLB | P06746 | 3/20 | 0.71 |
| ▸ | LMNA | P02545 | 5/20 | 0.69 |
| ▸ | NPC1 | O15118 | 3/20 | 0.69 |
| ▸ | RAB9A | P51151 | 3/20 | 0.69 |
| ▸ | GAA | P10253 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 8/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.63 |
| ▸ | PTPRE | P23469 | 1/20 | 0.60 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 3/20 | 0.55 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8569537 | 0.88 | HTT (1.00) | HTTSMN1; SMN2POLBLMNANPC1 | |
| SCHEMBL6379151 | 0.82 | TAS1R3 (0.69) | HTTSMN1; SMN2POLBLMNANPC1 | |
| SCHEMBL24232837 | 0.81 | BLM (0.80) | HTTSMN1; SMN2POLBLMNARAB9A | |
| SCHEMBL8561964 | 0.77 | HTT (0.75) | HTTSMN1; SMN2POLBLMNANPC1 | |
| SCHEMBL14758505 | 0.76 | MEN1 (0.75) | HTTSMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL5183426 | 0.76 | MEN1 (0.79) | HTTSMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL14758344 | 0.76 | SLC2A1 (1.00) | HTTSMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL11562419 | 0.75 | SMN1; SMN2 (0.73) | HTTSMN1; SMN2POLBLMNANPC1 | |
| SCHEMBL5183171 | 0.75 | MEN1 (0.77) | HTTSMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL20910875 | 0.74 | SLC2A1 (0.84) | HTTSMN1; SMN2LMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |