SCHEMBL8566048

SCHEMBL8566048

Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)cccn2c1Br

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8566050 1.00 BDKRB2 (1.00) BDKRB2
Hydrochloric Acid SCHEMBL8560282 0.99 BDKRB2 (1.00) BDKRB2
Hydrochloric Acid SCHEMBL8560280 0.99 BDKRB2 (1.00) BDKRB2
SCHEMBL8560186 0.98 BDKRB2 (0.96) BDKRB2
SCHEMBL8560190 0.98 BDKRB2 (0.96) BDKRB2
Hydrochloric Acid SCHEMBL8564394 0.98 BDKRB2 (0.96) BDKRB2
Hydrochloric Acid SCHEMBL8564391 0.98 BDKRB2 (0.96) BDKRB2
SCHEMBL8569373 0.94 BDKRB2 (0.89) BDKRB2
SCHEMBL8569377 0.94 BDKRB2 (0.89) BDKRB2
Hydrochloric Acid SCHEMBL8566377 0.93 BDKRB2 (0.89) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0596406-B1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO (JP) 1998-12-16 EP disclosed
EP-0596406-A1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-05-11 EP disclosed