SCHEMBL8566098

SCHEMBL8566098

Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CN(Cc4ccccc4)C(=O)CN)c3Cl)cccn2c1Br

nearest known ligand 0.80

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 10/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8565365 0.99 BDKRB2 (0.70) BDKRB2
SCHEMBL8564878 0.91 BDKRB2 (0.71) BDKRB2
SCHEMBL8565219 0.89 BDKRB2 (0.80) BDKRB2
SCHEMBL8565863 0.88 BDKRB2 (0.80) BDKRB2
Hydrochloric Acid SCHEMBL8559844 0.87 BDKRB2 (0.80) BDKRB2
SCHEMBL8562163 0.87 BDKRB2 (0.74) BDKRB2
Hydrochloric Acid SCHEMBL8564984 0.86 BDKRB2 (0.74) BDKRB2
SCHEMBL8560463 0.86 BDKRB2 (0.70) BDKRB2
SCHEMBL8562674 0.85 BDKRB2 (0.79) BDKRB2
Hydrochloric Acid SCHEMBL8558841 0.85 BDKRB2 (0.71) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0596406-B1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO (JP) 1998-12-16 EP disclosed
US-5574042-A ANTAGONIST FOR BRADYKININS AS ANTIALLERGENS, AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS, SHOCK OR PAIN FUJISAWA PHARMACEUTICAL CO., LTD (JP) 1996-11-12 US disclosed
EP-0596406-A1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-05-11 EP disclosed