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Phthalimide

Phthalimide

SCHEMBL8566252

CC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl.O=C1NC(=O)c2ccccc21

nearest known ligand 0.84

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Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ BDKRB2 P30411 4/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8560851 0.92 BDKRB2 (0.81) BDKRB2
Hydrochloric Acid SCHEMBL8566083 0.91 BDKRB2 (0.81) BDKRB2
SCHEMBL9078136 0.87 BDKRB2 (0.69) BDKRB2
Hydrochloric Acid SCHEMBL8562779 0.86 BDKRB2 (0.69) BDKRB2
SCHEMBL8560039 0.85 BDKRB2 (0.67) BDKRB2
Hydrochloric Acid SCHEMBL8565021 0.85 BDKRB2 (0.68) BDKRB2
SCHEMBL8566242 0.84 BDKRB2 (0.72) BDKRB2
SCHEMBL8568369 0.84 BDKRB2 (0.70) BDKRB2
SCHEMBL8566744 0.84 BDKRB2 (0.65) BDKRB2
Phthalimide SCHEMBL8567469 0.84 BDKRB2 (0.49) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0596406-B1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO (JP) 1998-12-16 — — EP disclosed
US-5574042-A ANTAGONIST FOR BRADYKININS AS ANTIALLERGENS, AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS, SHOCK OR PAIN FUJISAWA PHARMACEUTICAL CO., LTD (JP) 1996-11-12 — — US disclosed
EP-0596406-A1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-05-11 — — EP disclosed