Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.51 |
| ▸ | HTR2A | P28223 | 3/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
| ▸ | HTR1D | P28221 | 2/20 | 0.51 |
| ▸ | HRH1 | P35367 | 2/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.51 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.47 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MLNR | O43193 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1994507 | 1.00 | HTR1A (0.51) | HTR1AHTR2AKCNH2HTR1DHRH1 | |
| SCHEMBL1994505 | 1.00 | HTR1A (0.51) | HTR1AHTR2AKCNH2HTR1DHRH1 | |
| SCHEMBL4382179 | 0.98 | HTR1A (0.50) | HTR1AHTR2AKCNH2HTR1DHRH1 | |
| SCHEMBL10326683 | 0.98 | HTR1A (0.50) | HTR1AHTR2AKCNH2HTR1DHRH1 | |
| SCHEMBL1232420 | 0.98 | HTR1A (0.50) | HTR1AHTR2AKCNH2HTR1DHRH1 | |
| Hydrochloric Acid SCHEMBL8563154 | 0.98 | HTR1A (0.50) | HTR1AHTR2AKCNH2HTR1DHRH1 | |
| SCHEMBL1997768 | 0.98 | HTR1A (0.50) | HTR1AHTR2AKCNH2HTR1DHRH1 | |
| Hydrochloric Acid SCHEMBL8561237 | 0.96 | HTR1A (0.49) | HTR1AHTR2AKCNH2HTR1DHRH1 | |
| SCHEMBL10264864 | 0.96 | HTR1A (0.51) | HTR1AHTR2AKCNH2HTR1DHRH1 | |
| SCHEMBL16716869 | 0.93 | HTR1A (0.45) | HTR1AHTR2AKCNH2HTR1DHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438989-B1 | USE OF ASYMMETRIC HYDROGENATION CATALYST | TAKASAGO PERFUMERY CO LTD (JP) | 2016-04-13 | — | — | EP | disclosed |
| EP-2543437-A2 | HOMOGENEOUS ASYMMETRIC HYDROGENATION CATALYST | Takasago International Corporation (JP) | 2013-01-09 | — | — | EP | disclosed |
| US-5756730-A | Process for preparing analgesic compounds | SANKYO COMPANY, LIMITED (JP) | 1998-05-26 | — | — | US | disclosed |
| US-5656758-A | AMIDATION OF AN AMINE-CONTAINING THIOMORPHOLINE OR PIPERAZINE COMPOUND | SANKYO COMPANY, LIMITED (JP) | 1997-08-12 | — | — | US | disclosed |
| US-5512567-A | KAPPA-RECEPTOR AGONISTS | SANKYO COMPANY, LIMITED (JP) | 1996-04-30 | — | — | US | disclosed |
| US-5270327-A | Piperidine derivatives | SANKYO COMPANY, LIMITED (JP) | 1993-12-14 | — | — | US | disclosed |
| EP-0356247-B1 | ANALGESIC CARBOXYLIC ACID AMIDE DERIVATIVES | Sankyo Company Limited (JP) | 1993-03-17 | — | — | EP | disclosed |
| US-RE33906-E | Cyclic carboxamide derivatives and their use as analgesics | DR.LO.ZAMBELETTI S.P.A. (IT) | 1992-04-28 | — | — | US | disclosed |
| US-5021413-A | Analgesic thiomorpholins their preparation, and pharmaceutical compositions containing them | SANKYO COMPANY LIMITED (JP) | 1991-06-04 | — | — | US | disclosed |
| EP-0232612-B1 | AZACYCLIC COMPOUNDS, PROCESSES FOR THEIR PREPARATION, AND THEIR USE AS PHARMACEUTICALS | Dr. Lo. Zambeletti S.p.A. (IT) | 1990-04-04 | — | — | EP | disclosed |
| EP-0356247-A1 | Analgesic carboxylic acid amide derivatives | Sankyo Company Limited (JP) | 1990-02-28 | — | — | EP | disclosed |
| US-4826819-A | Piperidine analgesics | DR. LO ZAMBELETTI S.P.A. (IT) | 1989-05-02 | — | — | US | disclosed |
| US-4801585-A | Cyclic carboxamide derivatives and their use as analgesics | DR.LO.ZAMBELETTI S.P.A. (IT) | 1989-01-31 | — | — | US | disclosed |
| EP-0260041-A1 | 1-Acyl-substituted piperidine derivatives | Dr. Lo. Zambeletti S.p.A. (IT) | 1988-03-16 | — | — | EP | disclosed |
| EP-0232612-A1 | Azacyclic compounds, processes for their preparation, and their use as pharmaceuticals | Dr. Lo. Zambeletti S.p.A. (IT) | 1987-08-19 | — | — | EP | disclosed |