Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.55 |
| ▸ | AKT2 | P31751 | 2/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 14/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL213843 | 0.89 | PTGS2 (0.58) | AKT1AKT2PTGS2PTGS1 | |
| SCHEMBL8560259 | 0.82 | PTGS2 (0.61) | PTGS2PTGS1 | |
| SCHEMBL8564918 | 0.82 | PTGS2 (0.60) | AKT1AKT2PTGS2PTGS1 | |
| SCHEMBL8564646 | 0.81 | PTGS2 (0.58) | AKT1AKT2PTGS2PTGS1NR1H2 | |
| SCHEMBL8562195 | 0.80 | PTGS2 (0.55) | AKT1AKT2PTGS2PTGS1 | |
| SCHEMBL8563504 | 0.79 | PTGS2 (0.54) | PTGS2PTGS1NR1H2NR1H3 | |
| SCHEMBL8568965 | 0.79 | PTGS2 (0.56) | PTGS2PTGS1NR1H2NR1H3 | |
| SCHEMBL8566479 | 0.79 | PTGS2 (0.56) | PTGS2PTGS1NR1H2NR1H3 | |
| SCHEMBL8564319 | 0.79 | PTGS2 (0.59) | PTGS2PTGS1NR1H2NR1H3 | |
| SCHEMBL13743031 | 0.75 | GRIA1 (0.45) | AKT1AKT2PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819127-A1 | IMIDAZO [1,2-a]PYRIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1998-01-21 | — | — | EP | disclosed |
| WO-1996031509-A1 | IMIDAZO[1,2-a]PYRIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1996-10-10 | — | — | WO | disclosed |