Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL856503 | 0.79 | KMT2A (0.47) | KMT2AMEN1MAPTGFERLMNA | |
| SCHEMBL857159 | 0.74 | HSD17B10 (0.44) | KMT2AMEN1MAPTHSD17B10KDM4E | |
| SCHEMBL855842 | 0.71 | MEN1 (0.44) | KMT2AMEN1MAPTHSD17B10KDM4E | |
| SCHEMBL855297 | 0.70 | HDAC1 (0.47) | LMNANPC1 | |
| SCHEMBL27215273 | 0.69 | NPC1 (0.51) | MAPTLMNARAB9ANPC1 | |
| SCHEMBL9953246 | 0.67 | NPC1 (0.68) | KMT2AMEN1MAPTGFERLMNA | |
| SCHEMBL855353 | 0.67 | NPC1 (0.56) | KMT2AMEN1MAPTLMNAHSD17B10 | |
| SCHEMBL857862 | 0.67 | NPC1 (0.53) | KMT2AMEN1MAPTHSD17B10KDM4E | |
| SCHEMBL16463704 | 0.66 | MEN1 (0.63) | KMT2AMEN1MAPTGFERLMNA | |
| SCHEMBL488302 | 0.65 | LTA4H (0.57) | RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2640366-A2 | BENZOXAZEPINES AS INHIBITORS OF PI3K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE | Exelixis, Inc. (US) | 2013-09-25 | — | — | EP | disclosed |
| WO-2012068096-A2 | BENZOXAZEPINES AS INHIBITORS OF PI3K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2012-05-24 | — | — | WO | disclosed |
| EP-2432779-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | Exelixis, Inc. (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010135524-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | EXELIXIS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |