Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 15/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8566901 | 0.92 | LTB4R2 (0.42) | LTB4R2AGTR1ALDH1A1MAPTGAA | |
| SCHEMBL7480667 | 0.87 | L3MBTL1 (0.47) | ALDH1A1MAPTGAASMN1; SMN2L3MBTL1 | |
| SCHEMBL7015019 | 0.82 | LTB4R2 (0.44) | LTB4R2AGTR1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL9586936 | 0.82 | FNTA (0.39) | LTB4R2ALDH1A1MAPTGAASMN1; SMN2 | |
| SCHEMBL16824598 | 0.81 | AGT (0.39) | LTB4R2AGTR1ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL9586519 | 0.81 | FNTA (0.40) | LTB4R2ALDH1A1MAPTGAASMN1; SMN2 | |
| SCHEMBL9586285 | 0.81 | FNTA (0.39) | LTB4R2ALDH1A1MAPTGAASMN1; SMN2 | |
| SCHEMBL9587776 | 0.80 | FNTA (0.41) | LTB4R2ALDH1A1MAPTGAASMN1; SMN2 | |
| SCHEMBL9586917 | 0.79 | FNTA (0.41) | ALDH1A1MAPTGAASMN1; SMN2L3MBTL1 | |
| SCHEMBL4939408 | 0.79 | LTB4R2 (0.41) | LTB4R2ALDH1A1MAPTSMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0603001-B1 | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO CO (JP) | 1998-08-26 | — | — | EP | disclosed |
| US-5459148-A | Cardiovascular disorders | SANKYO COMPANY, LIMITED (JP) | 1995-10-17 | — | — | US | disclosed |
| EP-0603001-A1 | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO COMPANY LIMITED (JP) | 1994-06-22 | — | — | EP | disclosed |