Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 known ✓ | P25021 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8899316 | 1.00 | SIGMAR1 (0.47) | SIGMAR1GAAMEN1KMT2AHRH2 | |
| Bromide SCHEMBL8901003 | 0.87 | SIGMAR1 (0.50) | SIGMAR1MEN1KMT2A | |
| Bromide SCHEMBL8563260 | 0.87 | SIGMAR1 (0.50) | SIGMAR1MEN1KMT2A | |
| Bromide SCHEMBL8563399 | 0.87 | HDAC1 (0.43) | MEN1KMT2A | |
| Bromide SCHEMBL8563395 | 0.87 | HDAC1 (0.43) | MEN1KMT2A | |
| Bromide SCHEMBL8559098 | 0.84 | KCNH2 (0.44) | — | |
| Bromide SCHEMBL8900117 | 0.84 | KCNH2 (0.44) | — | |
| Bromide SCHEMBL26663611 | 0.83 | BTK (0.46) | GAAMEN1KMT2A | |
| Bromide SCHEMBL8480945 | 0.81 | CYP3A4 (0.41) | SIGMAR1MEN1KMT2A | |
| Bromide SCHEMBL8478935 | 0.81 | CYP3A4 (0.41) | SIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5804577-A | ANTIBIOTICS | HOFFMANN-LA ROCHE INC. (US) | 1998-09-08 | — | — | US | disclosed |
| EP-0761673-A1 | Cephalosporin derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-12 | — | — | EP | disclosed |