Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NCF1 | P14598 | 8/20 | 0.36 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19122690 | 0.79 | KMT2A (0.51) | APPENPP2NPC1MAPTRAB9A | |
| SCHEMBL9784162 | 0.78 | HTR1B (0.47) | NPC1MAPTRAB9APOLB | |
| Bromide SCHEMBL9732194 | 0.77 | HTR1B (0.46) | NPC1MAPTRAB9APOLB | |
| SCHEMBL7406721 | 0.72 | APP (0.40) | APPNPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL17848625 | 0.72 | APP (0.49) | APPNPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL8146789 | 0.72 | NPC1 (0.66) | APPNPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL8363045 | 0.71 | POLB (0.57) | ENPP2NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL8140756 | 0.71 | NPC1 (0.47) | NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL11016307 | 0.70 | LTA4H (0.52) | ENPP2NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4017940 | 0.70 | MAPT (0.44) | APPENPP2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0431943-B1 | Spiro(pyran)piperidine derivatives | MERCK & CO INC (US) | 1998-07-15 | — | — | EP | disclosed |
| US-5633247-A | ANTIARRTHYMIA AGENT | MERCK & CO., INC. (US) | 1997-05-27 | — | — | US | disclosed |
| US-5206240-A | Antiarrhythmia agents | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| US-5112824-A | Benzofurazan compounds | MERCK & CO., INC. (US) | 1992-05-12 | — | — | US | disclosed |
| EP-0431943-A2 | Nitrogen-containing spirocycles | MERCK & CO. INC. (US) | 1991-06-12 | — | — | EP | disclosed |