Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 16/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8567921 | 0.74 | CA1 (0.39) | BACE1CA1CA2CA7BACE2 | |
| SCHEMBL8562900 | 0.74 | CA1 (0.39) | BACE1CA1CA2CA7BACE2 | |
| SCHEMBL5619596 | 0.67 | KLK5 (0.62) | BACE1KLK5APPPSEN1PSEN2 | |
| SCHEMBL9394616 | 0.67 | KLK5 (0.62) | BACE1KLK5APPPSEN1PSEN2 | |
| SCHEMBL6045015 | 0.64 | KLK5 (0.41) | BACE1KLK5 | |
| SCHEMBL6044435 | 0.64 | KLK5 (0.45) | BACE1KLK5APPPSEN1PSEN2 | |
| SCHEMBL6044566 | 0.64 | REN (0.51) | BACE1KLK5APPPSEN1PSEN2 | |
| SCHEMBL6044515 | 0.63 | KLK5 (0.42) | BACE1KLK5 | |
| SCHEMBL13413128 | 0.62 | CA1 (0.53) | BACE1CA1CA2CA7 | |
| SCHEMBL8562922 | 0.62 | CYP2D6 (0.39) | CA1CA2CA7KLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |