SCHEMBL8567575

SCHEMBL8567575

CC(=O)N(C)CC(=O)Nc1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl

nearest known ligand 0.78

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 2/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8560301 0.91 BDKRB2 (0.59) BDKRB2
SCHEMBL8559412 0.88 BDKRB2 (0.62) BDKRB2
SCHEMBL8559029 0.88 BDKRB2 (0.69) BDKRB2
SCHEMBL8560172 0.87 BDKRB2 (0.66) BDKRB2
SCHEMBL8567795 0.84 BDKRB2 (0.79) BDKRB2
SCHEMBL8570185 0.83 BDKRB2 (0.43) BDKRB2
SCHEMBL8565738 0.83 BDKRB2 (0.70) BDKRB2
SCHEMBL8563737 0.83 BDKRB2 (0.66) BDKRB2
SCHEMBL8567587 0.83 BDKRB2 (0.60) BDKRB2
SCHEMBL8562661 0.82 BDKRB2 (0.71) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0596406-B1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO (JP) 1998-12-16 EP disclosed
US-5750699-A HALOGENATING OF CORRESPONDING COMPOUND FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-05-12 US disclosed
US-5574042-A ANTAGONIST FOR BRADYKININS AS ANTIALLERGENS, AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS, SHOCK OR PAIN FUJISAWA PHARMACEUTICAL CO., LTD (JP) 1996-11-12 US disclosed
EP-0596406-A1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-05-11 EP disclosed