⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28444613 | 0.77 | — | — | |
| SCHEMBL20660050 | 0.76 | — | — | |
| SCHEMBL630894 | 0.73 | — | — | |
| SCHEMBL3933294 | 0.73 | — | — | |
| SCHEMBL29162290 | 0.72 | — | — | |
| SCHEMBL311015 | 0.72 | — | — | |
| SCHEMBL6863642 | 0.72 | — | — | |
| SCHEMBL5196121 | 0.72 | — | — | |
| SCHEMBL4023019 | 0.72 | — | — | |
| SCHEMBL1815629 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109467535-A | A kind of preparation method of Fenbendazole | 江苏宝众宝达药业有限公司 | 2019-03-15 | — | — | CN | claimed |
| CN-105669520-A | Tryptophan basic skeleton-containing o-phenylenediamine selective histone deacetylase inhibitor and its preparation method and use | 山东大学 | 2016-06-15 | — | — | CN | claimed |
| CN-103728294-B | Bisbenzimidazole connection carbazole compound is for specific binding nucleic acid G-tetra-chain body structures and in the application of antineoplastic | INSTITUTE OF CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) | 2016-05-11 | — | — | CN | claimed |
| CN-103728294-A | Applications of bisbenzimidazole bicarbazole compound in specific binding nucleic acid G-quadruplex structure and anti-tumor drug | CHINESE ACAD INST CHEMISTRY | 2014-04-16 | — | — | CN | claimed |
| WO-2021138392-A1 | AMINOPYRIMIDINE COMPOUNDS | TYRA BIOSCIENCES, INC. (US) | 2021-07-08 | — | — | WO | disclosed |
| CN-110354128-A | Pyrimidine FGFR4 inhibitors | 卫材R&D管理有限公司 | 2019-10-22 | — | — | CN | disclosed |
| CN-110290792-A | Morphinan derivative and its composition for being used to treat autoimmunity, inflammation or the relevant obstacle of infection | 景凯生物科技股份有限公司 | 2019-09-27 | — | — | CN | disclosed |
| CN-110214138-A | Pyrimidine compounds and their pharmaceutical use | 韩美药品株式会社 | 2019-09-06 | — | — | CN | disclosed |
| CN-110177784-A | One kind containing aromatic compound, preparation method, pharmaceutical composition and application | 罗欣药业(上海)有限公司 | 2019-08-27 | — | — | CN | disclosed |
| CN-105899490-B | Pyrimidine FGFR4 Inhibitors | 卫材R&D管理有限公司 | 2019-07-23 | — | — | CN | disclosed |
| CN-110049983-A | Medical compounds | 细胞中心有限公司 | 2019-07-23 | — | — | CN | disclosed |
| CN-109843874-A | Inhibitor as PARP1, PARP2 and/or tubulin can be used for the phthalazine derivatives for the treatment of cancer | 加利福尼亚大学董事会 | 2019-06-04 | — | — | CN | disclosed |
| CN-105188718-A | Chelants for advanced glycation end product (AGE) precursors | GENZYME CORP | 2015-12-23 | — | — | CN | disclosed |
| CN-104024248-A | SERINE/THREONINE PAK1 INHIBITORS | HOFFMANN LA ROCHE | 2014-09-03 | — | — | CN | disclosed |
| CN-103728294-A | Applications of bisbenzimidazole bicarbazole compound in specific binding nucleic acid G-quadruplex structure and anti-tumor drug | CHINESE ACAD INST CHEMISTRY | 2014-04-16 | — | — | CN | disclosed |
| CN-102170882-B | Compositions and methods of treating amyloid disease | TREVENTIS CORP | 2014-04-02 | — | — | CN | disclosed |
| CN-101472585-B | Antibacterial compositions | BIOTA EUROPE LTD | 2013-12-04 | — | — | CN | disclosed |
| EP-2432779-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | Exelixis, Inc. (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010135524-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | EXELIXIS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |
| EP-1497287-B1 | Quinoline derivatives in combination with 5-FU or CPT-11 for use in the treatment of cancer | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2010-11-24 | — | — | EP | disclosed |