Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.78 |
| ▸ | BCHE | P06276 | 2/20 | 0.57 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.57 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.57 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | BACE1 | P56817 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 3/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TOP2A | P11388 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1775576 | 0.89 | TSHR (0.64) | TSHRBCHETRPC3TRPC4TRPC5 | |
| SCHEMBL8567802 | 0.88 | TSHR (1.00) | TSHRBCHETRPC3TRPC4TRPC5 | |
| SCHEMBL2446553 | 0.88 | BACE1 (0.69) | TSHRBCHETRPC3TRPC4TRPC5 | |
| SCHEMBL2445746 | 0.86 | BACE1 (0.73) | TSHRBCHETRPC3TRPC4TRPC5 | |
| SCHEMBL7521873 | 0.85 | TSHR (0.73) | TSHRBCHETRPC3TRPC4TRPC5 | |
| Bromide SCHEMBL7520808 | 0.84 | TSHR (0.72) | TSHRBCHETRPC3TRPC4TRPC5 | |
| SCHEMBL7519030 | 0.81 | DRD4 (0.67) | TSHRBACE1KDM4EPARP1RAB9A | |
| Bromide SCHEMBL7519988 | 0.81 | DRD4 (0.65) | TSHRBACE1KDM4EPARP1RAB9A | |
| SCHEMBL17749563 | 0.80 | TSHR (0.86) | TSHRBCHETRPC3TRPC4TRPC5 | |
| SCHEMBL12332532 | 0.80 | BACE1 (0.69) | TSHRBCHETRPC3TRPC4TRPC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0571253-B1 | Benzimidazole derivatives with antidiabetic and antiplatelet aggregation activity | ADIR (FR) | 1998-11-04 | — | — | EP | disclosed |
| US-5639756-A | ANTIDIABETIC AGENTS | ADIR ET COMPAGNIE (FR) | 1997-06-17 | — | — | US | disclosed |
| US-5623073-A | ANTIDIABETIC AGENT | ADIR ET COMPAGNIE (FR) | 1997-04-22 | — | — | US | disclosed |
| EP-0571253-A1 | Benzimidazole derivatives with antidiabetic and antiplatelet aggregation activity | ADIR ET COMPAGNIE (FR) | 1993-11-24 | — | — | EP | disclosed |