Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 14/20 | 0.61 |
| ▸ | ERBB4 | Q15303 | 12/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.60 |
| ▸ | JAK3 | P52333 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8567648 | 1.00 | EGFR (0.61) | EGFRERBB2ERBB4MEN1KMT2A | |
| SCHEMBL8565858 | 0.92 | EGFR (0.53) | EGFRERBB2ERBB4MEN1KMT2A | |
| SCHEMBL8565853 | 0.92 | EGFR (0.53) | EGFRERBB2ERBB4MEN1KMT2A | |
| SCHEMBL8565496 | 0.87 | EGFR (0.70) | EGFRERBB2ERBB4MEN1KMT2A | |
| SCHEMBL8567268 | 0.86 | EGFR (0.61) | EGFRERBB2ERBB4MEN1KMT2A | |
| SCHEMBL8567263 | 0.86 | EGFR (0.61) | EGFRERBB2ERBB4MEN1KMT2A | |
| SCHEMBL8599966 | 0.82 | EGFR (0.48) | EGFRERBB2GRM1HPGDHTT | |
| SCHEMBL8599962 | 0.82 | EGFR (0.48) | EGFRERBB2GRM1HPGDHTT | |
| SCHEMBL8316770 | 0.82 | EGFR (0.77) | EGFRERBB2ERBB4MEN1KMT2A | |
| SCHEMBL6997215 | 0.82 | EGFR (0.77) | EGFRERBB2ERBB4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885226-A1 | 4-AMINO PYRIMIDINE DERIVATES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | Dr. Karl Thomae GmbH (DE) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032881-A1 | 4-AMINO PYRIMIDINE DERIVATES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | DR. KARL THOMAE GMBH (DE) | 1997-09-12 | — | — | WO | disclosed |