Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 14/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 11/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8568737 | 0.90 | LTB4R (0.49) | LTB4RLTB4R2 | |
| SCHEMBL8569026 | 0.89 | NR1H4 (0.44) | NR1H4LTB4RLTB4R2 | |
| SCHEMBL8565242 | 0.84 | LTB4R (0.39) | NR1H4LTB4RLTB4R2ESR1KDM4E | |
| SCHEMBL6536626 | 0.82 | LTB4R (0.51) | LTB4RLTB4R2 | |
| SCHEMBL7631126 | 0.81 | LTB4R (0.49) | LTB4RLTB4R2 | |
| SCHEMBL7645606 | 0.80 | LTB4R (0.54) | LTB4RLTB4R2 | |
| SCHEMBL8561315 | 0.76 | LTB4R (0.48) | LTB4RLTB4R2 | |
| SCHEMBL9047532 | 0.75 | LTB4R (0.39) | NR1H4LTB4RLTB4R2 | |
| SCHEMBL27570394 | 0.74 | LTB4R (0.49) | LTB4RLTB4R2 | |
| SCHEMBL8567609 | 0.74 | LTB4R (0.61) | LTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544488-B1 | Substituted phenyl phenol leukotriene antagonists | LILLY CO ELI (US) | 1998-03-11 | — | — | EP | disclosed |
| WO-1996036347-A1 | USE OF LEUKOTRIENE ANTAGONISTS FOR ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1996-11-21 | — | — | WO | disclosed |
| EP-0743064-A1 | Leukotriene antagonists for use in the treatment or prevention of alzheimer's disease | ELI LILLY AND COMPANY (US) | 1996-11-20 | — | — | EP | disclosed |
| US-5462954-A | Antiinflammatory, antiallergens; treating asthma | ELI LILLY AND COMPANY (US) | 1995-10-31 | — | — | US | disclosed |
| EP-0544488-A2 | Substituted phenyl phenol leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1993-06-02 | — | — | EP | disclosed |