Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 7/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL856773 | 0.76 | PIK3CA (0.40) | CREBBPPDGFRBCYP2C19ALDH1A1CLK4 | |
| SCHEMBL856772 | 0.75 | PIK3CA (0.38) | CREBBPPDGFRBCYP2C19ALDH1A1CLK4 | |
| SCHEMBL3757572 | 0.74 | PIK3CA (0.39) | CREBBPPDGFRBCYP2C19ALDH1A1CLK4 | |
| SCHEMBL6126132 | 0.73 | PIK3CA (0.40) | CREBBPPDGFRBCYP2C19ALDH1A1CLK4 | |
| SCHEMBL856147 | 0.71 | CYP3A4 (0.41) | CYP2C19ALDH1A1CLK4TSHRMAPK1 | |
| SCHEMBL857187 | 0.70 | PIK3CA (0.51) | CYP2C19ALDH1A1CLK4TSHRMAPK1 | |
| SCHEMBL3763910 | 0.69 | PRMT5 (0.45) | CYP2C19ALDH1A1CLK4TSHRMAPK1 | |
| SCHEMBL858375 | 0.69 | PIK3CA (0.46) | CREBBPALDH1A1TSHRMAPK1MEN1 | |
| SCHEMBL3716268 | 0.69 | PIK3CA (0.42) | CREBBPCYP2C19ALDH1A1CLK4TSHR | |
| SCHEMBL3807014 | 0.68 | PIK3CA (0.45) | ALDH1A1MEN1KMT2APIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432779-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | Exelixis, Inc. (US) | 2012-03-28 | — | — | EP | disclosed |