Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6126132 | 0.89 | PIK3CA (0.40) | PIK3CAPDGFRBCREBBPCLK4MTOR | |
| SCHEMBL3757572 | 0.84 | PIK3CA (0.39) | PIK3CAPDGFRBCREBBPCLK4MTOR | |
| SCHEMBL856147 | 0.80 | CYP3A4 (0.41) | PIK3CACLK4MAPK1ALDH1A1TSHR | |
| SCHEMBL7858604 | 0.77 | LMNA (0.47) | PIK3CARAF1BRAFCREBBPCLK4 | |
| SCHEMBL856773 | 0.77 | PIK3CA (0.40) | PIK3CAPDGFRBCREBBPCLK4MTOR | |
| SCHEMBL3716268 | 0.76 | PIK3CA (0.42) | PIK3CACREBBPCLK4MAPK1ALDH1A1 | |
| SCHEMBL3763910 | 0.75 | PRMT5 (0.45) | PIK3CAPRMT5CLK4MAPK1ALDH1A1 | |
| SCHEMBL3719872 | 0.75 | CYP3A4 (0.42) | CLK4MAPK1ALDH1A1TSHRCYP2C19 | |
| SCHEMBL856771 | 0.75 | CREBBP (0.37) | PIK3CAPDGFRBPRMT5CREBBPCLK4 | |
| SCHEMBL13056673 | 0.74 | MTNR1B (0.44) | PIK3CAPDGFRBCLK4MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432779-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | Exelixis, Inc. (US) | 2012-03-28 | — | — | EP | disclosed |