Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 6/20 | 0.44 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | NPY1R | P25929 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8835421 | 0.78 | POLB (0.50) | NCOA1NCOA3POLBMAPTMEN1 | |
| SCHEMBL10309413 | 0.76 | MAPT (0.56) | NCOA1NCOA3POLBMAPTMEN1 | |
| SCHEMBL4079065 | 0.70 | POLB (0.54) | NCOA1NCOA3POLBMAPTMEN1 | |
| SCHEMBL1982991 | 0.70 | ALDH1A1 (0.59) | NCOA1NCOA3POLBMAPTMEN1 | |
| SCHEMBL2004290 | 0.70 | POLB (0.54) | NCOA1NCOA3POLBMAPTMEN1 | |
| SCHEMBL12101490 | 0.70 | POLB (0.54) | NCOA1NCOA3POLBMAPTMEN1 | |
| SCHEMBL31233910 | 0.70 | POLB (0.54) | NCOA1NCOA3POLBMAPTMEN1 | |
| SCHEMBL3037149 | 0.70 | POLB (0.54) | NCOA1NCOA3POLBMAPTMEN1 | |
| SCHEMBL8381644 | 0.70 | POLB (0.54) | NCOA1NCOA3POLBMAPTMEN1 | |
| SCHEMBL7488303 | 0.70 | KDM1A (0.54) | PDE7AMAPTMEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |
| US-5624937-A | TREATMENT OF ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1997-04-29 | — | — | US | disclosed |