Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.53 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.52 |
| ▸ | FBP1 | P09467 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | FLT4 | P35916 | 1/20 | 0.52 |
| ▸ | CLK1 | P49759 | 1/20 | 0.52 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.52 |
| ▸ | TEK | Q02763 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.51 |
| ▸ | DUS2 | Q9NX74 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8568027 | 1.00 | EGFR (0.54) | EGFRERBB2ERBB4KDRAURKA | |
| SCHEMBL8567268 | 0.93 | EGFR (0.61) | EGFRERBB2ERBB4KDRAURKA | |
| SCHEMBL8567263 | 0.93 | EGFR (0.61) | EGFRERBB2ERBB4KDRAURKA | |
| SCHEMBL8565858 | 0.86 | EGFR (0.53) | EGFRERBB2ERBB4KDRAURKA | |
| SCHEMBL8565853 | 0.86 | EGFR (0.53) | EGFRERBB2ERBB4KDRAURKA | |
| SCHEMBL8318239 | 0.84 | KCNH2 (0.51) | EGFRERBB2ERBB4KDRPDGFRB | |
| SCHEMBL8318242 | 0.84 | KCNH2 (0.51) | EGFRERBB2ERBB4KDRPDGFRB | |
| SCHEMBL8601242 | 0.84 | IRAK4 (0.53) | EGFRERBB2ERBB4KDRAURKA | |
| SCHEMBL8601949 | 0.84 | CSNK2A1 (0.54) | EGFRERBB2ERBB4KDRAURKA | |
| SCHEMBL8601945 | 0.84 | CSNK2A1 (0.54) | EGFRERBB2ERBB4KDRAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885226-A1 | 4-AMINO PYRIMIDINE DERIVATES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | Dr. Karl Thomae GmbH (DE) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032881-A1 | 4-AMINO PYRIMIDINE DERIVATES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | DR. KARL THOMAE GMBH (DE) | 1997-09-12 | — | — | WO | disclosed |