Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 7/20 | 0.45 |
| ▸ | PRCP | P42785 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.43 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.43 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.43 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.43 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318242 | 1.00 | KCNH2 (0.51) | KCNH2EGFRPRCPKMT2AMEN1 | |
| SCHEMBL8799034 | 0.85 | KCNH2 (0.52) | KCNH2EGFRERBB2PDGFRBMAPKAPK2 | |
| SCHEMBL8799037 | 0.85 | KCNH2 (0.52) | KCNH2EGFRERBB2PDGFRBMAPKAPK2 | |
| SCHEMBL8567263 | 0.84 | EGFR (0.61) | EGFRKMT2AMEN1ERBB2ERBB4 | |
| SCHEMBL8567268 | 0.84 | EGFR (0.61) | EGFRKMT2AMEN1ERBB2ERBB4 | |
| SCHEMBL8568027 | 0.84 | EGFR (0.54) | EGFRKMT2AMEN1ERBB2ERBB4 | |
| SCHEMBL8568035 | 0.84 | EGFR (0.54) | EGFRKMT2AMEN1ERBB2ERBB4 | |
| SCHEMBL8799684 | 0.84 | KCNH2 (0.47) | KCNH2EGFRPRCPKMT2AMEN1 | |
| SCHEMBL7858523 | 0.84 | KCNH2 (0.47) | KCNH2EGFRPRCPKMT2AMEN1 | |
| SCHEMBL7701769 | 0.83 | KCNH2 (0.49) | KCNH2EGFRPRCPKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-A1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | Dr. Karl Thomae GmbH (DE) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997032880-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | DR. KARL THOMAE GMBH (DE) | 1997-09-12 | — | — | WO | disclosed |