Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 16/20 | 0.63 |
| ▸ | LTB4R2 | Q9NPC1 | 12/20 | 0.63 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | PPARD | Q03181 | 2/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8568443 | 0.90 | LTB4R (0.77) | LTB4RLTB4R2FFAR4FFAR1 | |
| SCHEMBL8566886 | 0.89 | LTB4R (0.68) | LTB4RLTB4R2 | |
| SCHEMBL7631004 | 0.87 | LTB4R (0.77) | LTB4RLTB4R2 | |
| SCHEMBL8563619 | 0.83 | LTB4R (0.77) | LTB4RLTB4R2 | |
| SCHEMBL8564455 | 0.83 | LTB4R (0.69) | LTB4RLTB4R2 | |
| SCHEMBL8567828 | 0.83 | LTB4R (0.70) | LTB4RLTB4R2 | |
| SCHEMBL8568217 | 0.82 | LTB4R (0.64) | LTB4RLTB4R2 | |
| SCHEMBL8567609 | 0.82 | LTB4R (0.61) | LTB4RLTB4R2FFAR4 | |
| SCHEMBL8562618 | 0.81 | LTB4R (0.60) | LTB4RLTB4R2 | |
| SCHEMBL8564113 | 0.81 | LTB4R (0.56) | LTB4RLTB4R2FFAR4FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544488-B1 | Substituted phenyl phenol leukotriene antagonists | LILLY CO ELI (US) | 1998-03-11 | — | — | EP | disclosed |
| EP-0743064-A1 | Leukotriene antagonists for use in the treatment or prevention of alzheimer's disease | ELI LILLY AND COMPANY (US) | 1996-11-20 | — | — | EP | disclosed |
| US-5462954-A | Antiinflammatory, antiallergens; treating asthma | ELI LILLY AND COMPANY (US) | 1995-10-31 | — | — | US | disclosed |
| EP-0544488-A2 | Substituted phenyl phenol leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1993-06-02 | — | — | EP | disclosed |