SCHEMBL8568595

SCHEMBL8568595

CC(C)(C)OC(=O)N1CCN(Cc2ccccc2)C(C(=O)O)C1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 2/20 0.50
JAK2 O60674 1/20 0.50
JAK1 P23458 1/20 0.50
STS P08842 1/20 0.47
OPRD1 P41143 1/20 0.45
OPRK1 P41145 1/20 0.45
BCHE P06276 2/20 0.45
HTR6 P50406 2/20 0.45
BRD4 O60885 1/20 0.45
USP30 Q70CQ3 3/20 0.45
KDM4E B2RXH2 1/20 0.45
PKM P14618 1/20 0.45
ACHE P22303 1/20 0.44
SCD O00767 1/20 0.43
SCD5 Q86SK9 1/20 0.43
CHRM2 P08172 1/20 0.43
CHRM4 P08173 1/20 0.43
CHRM1 P11229 1/20 0.43
CHRM3 P20309 1/20 0.43
GAA P10253 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31740665 1.00 GPR119 (0.50) GPR119JAK2JAK1STSOPRD1
SCHEMBL27006693 0.91 GPR119 (0.49) GPR119JAK2JAK1STSOPRD1
SCHEMBL4828897 0.90 GPR119 (0.48) GPR119JAK2JAK1STSOPRD1
SCHEMBL4828906 0.90 GPR119 (0.48) GPR119JAK2JAK1STSOPRD1
SCHEMBL30867751 0.89 GPR119 (0.50) GPR119JAK2JAK1STSOPRD1
SCHEMBL29060414 0.89 GPR119 (0.53) GPR119JAK2JAK1STSOPRD1
SCHEMBL17913813 0.89 GPR119 (0.50) GPR119JAK2JAK1STSOPRD1
SCHEMBL14198702 0.88 GPR119 (0.50) GPR119JAK2JAK1STSOPRD1
SCHEMBL12340707 0.88 GPR119 (0.50) GPR119JAK2JAK1STSOPRD1
SCHEMBL15055262 0.88 GPR119 (0.50) GPR119JAK2JAK1STSOPRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103923765-A Detergent Composition For Process Of Manufacturing Semiconductors And Displays COWON INNOTECH INC 2014-07-16 CN claimed
US-11999746-B2 Compounds GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2024-06-04 US disclosed
US-20240018161-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMA (US) 2024-01-18 US disclosed
US-20240018161-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMA (US) 2024-01-18 US disclosed
EP-4225447-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR Vertex Pharmaceuticals Incorporated (US) 2023-08-16 EP disclosed
WO-2022076625-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMACEUTICALS INCORPORATED (US) 2022-04-14 WO disclosed
WO-2022076625-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMACEUTICALS INCORPORATED (US) 2022-04-14 WO disclosed
US-20200055863-A1 COMPOUNDS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2020-02-20 US disclosed
US-10428078-B2 Compounds GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2019-10-01 US disclosed
EP-3172211-B1 TRICYCLIC IMIDAZO-PYRIMIDINONE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY LP-PLA2 GLAXOSMITHKLINE IP DEV LTD (GB) 2019-07-03 EP disclosed
US-20190023715-A1 COMPOUNDS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2019-01-24 US disclosed
US-10125141-B2 Compounds GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2018-11-13 US disclosed
US-9869027-B2 Cleaning composition and method of manufacturing metal wiring using the same SAMSUNG DISPLAY CO., LTD. (KR) 2018-01-16 US disclosed
US-20170204109-A1 Compounds GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2017-07-20 US disclosed
US-20160230289-A1 CLEANING COMPOSITION AND METHOD OF MANUFACTURING METAL WIRING USING THE SAME SAMSUNG DISPLAY CO LTD (KR) 2016-08-11 US disclosed
US-9340759-B2 Cleaning composition and method of manufacturing metal wiring using the same SAMSUNG DISPLAY CO., LTD. (KR) 2016-05-17 US disclosed
US-20150136728-A1 CLEANING COMPOSITION AND METHOD OF MANUFACTURING METAL WIRING USING THE SAME SAMSUNG DISPLAY CO., LTD. (KR) 2015-05-21 US disclosed
CN-104419326-A Slurry composition for chemical mechanical polishing COWON INNOTECH INC 2015-03-18 CN disclosed
CN-103923765-A Detergent Composition For Process Of Manufacturing Semiconductors And Displays COWON INNOTECH INC 2014-07-16 CN disclosed
US-5849746-A Substituted 1,4-piperazine-heteroaryl derivatives as 5-HT1D receptor agonists MERCK SHARP & DOHME LTD. (GB) 1998-12-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200055863-A1 COMPOUNDS PLAAT2, PLA2G12A, PLA2G1B GPR119 495/4885JAK2 4844/4885JAK1 4870/4885
US-20190023715-A1 COMPOUNDS PLAAT2, PLA2G12A, PLA2G1B GPR119 495/4885JAK2 4844/4885JAK1 4870/4885
US-20240018161-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR CFTR, SCNN1G, SCNN1B GPR119 788/4885JAK2 3824/4885JAK1 3836/4885
US-10125141-B2 Compounds PLAAT2, PLA2G12A, PLA2G1B GPR119 495/4885JAK2 4844/4885JAK1 4870/4885
US-10428078-B2 Compounds PLAAT2, PLA2G12A, PLA2G1B GPR119 495/4885JAK2 4844/4885JAK1 4870/4885
US-11999746-B2 Compounds PLAAT2, PLA2G12A, PLA2G1B GPR119 495/4885JAK2 4844/4885JAK1 4870/4885
US-20170204109-A1 Compounds PLAAT2, PLA2G12A, PLA2G1B GPR119 495/4885JAK2 4844/4885JAK1 4870/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.