Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.36 |
| ▸ | RARA | P10276 | 5/20 | 0.36 |
| ▸ | RARB | P10826 | 4/20 | 0.36 |
| ▸ | RARG | P13631 | 4/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.35 |
| ▸ | GOT1 | P17174 | 1/20 | 0.35 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8647515 | 0.91 | S1PR1 (0.35) | S1PR1HDAC11RARARARBRARG | |
| SCHEMBL5888282 | 0.86 | HDAC11 (0.41) | S1PR1HDAC11RARARARBRARG | |
| SCHEMBL7691709 | 0.83 | HDAC11 (0.42) | S1PR1HDAC11RARARARBRARG | |
| SCHEMBL8694379 | 0.82 | HDAC11 (0.33) | S1PR1HDAC11RARARARBRARG | |
| SCHEMBL5888269 | 0.82 | HDAC11 (0.36) | S1PR1HDAC11RARARARBRARG | |
| SCHEMBL8692343 | 0.82 | RARA (0.36) | S1PR1HDAC11RARARARBRARG | |
| SCHEMBL8691114 | 0.81 | PPARG (0.39) | S1PR1HDAC11RARARARBRARG | |
| SCHEMBL8696047 | 0.81 | HDAC11 (0.36) | S1PR1HDAC11RARARARBRARG | |
| SCHEMBL7689501 | 0.81 | S1PR1 (0.51) | S1PR1HDAC11RARARARBRARG | |
| SCHEMBL7686283 | 0.81 | RARA (0.48) | S1PR1HDAC11RARARARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0679628-B1 | Polyene derivatives, pharmaceutical and cosmetic composition containing them and their use | CIRD GALDERMA (FR) | 1998-04-22 | — | — | EP | disclosed |
| EP-0679628-A1 | Polyene derivatives, pharmaceutical and cosmetic composition containing them and their use | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) | 1995-11-02 | — | — | EP | disclosed |