Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CASR | P41180 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 3/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11430909 | 0.81 | NISCH (0.45) | NISCHHPGDCASRBRD4CREBBP | |
| SCHEMBL3972135 | 0.75 | NISCH (0.45) | NISCHHPGDCASRBRD4CREBBP | |
| SCHEMBL18601107 | 0.73 | HPGD (0.46) | NISCHHPGDCASRBRD4CREBBP | |
| SCHEMBL19392968 | 0.72 | BRD4 (0.54) | NISCHHPGDCASRBRD4CREBBP | |
| SCHEMBL517074 | 0.72 | BRD4 (0.54) | NISCHHPGDCASRBRD4CREBBP | |
| SCHEMBL8562489 | 0.71 | CASR (0.47) | NISCHHPGDCASRBRD4CREBBP | |
| SCHEMBL8562491 | 0.71 | CASR (0.47) | NISCHHPGDCASRBRD4CREBBP | |
| SCHEMBL8562492 | 0.71 | CASR (0.47) | NISCHHPGDCASRBRD4CREBBP | |
| SCHEMBL15158184 | 0.69 | HPGD (0.48) | NISCHHPGDCASRBRD4CREBBP | |
| SCHEMBL8564068 | 0.69 | NISCH (0.46) | NISCHHPGDCASRBRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0702004-A2 | 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amid derivatives | CIBA-GEIGY AG (CH) | 1996-03-20 | — | — | EP | disclosed |