Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 3/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.53 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.49 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.48 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3058464 | 0.96 | CCR5 (0.51) | CCR5JAK2JAK1USP30GPR119 | |
| SCHEMBL1586077 | 0.91 | JAK2 (0.55) | CCR5JAK2JAK1GPR119PDK1 | |
| SCHEMBL1586076 | 0.91 | JAK2 (0.55) | CCR5JAK2JAK1GPR119PDK1 | |
| SCHEMBL31229825 | 0.90 | PARP1 (0.52) | CCR5JAK2JAK1GPR119PDK1 | |
| SCHEMBL30923126 | 0.89 | JAK2 (0.53) | CCR5JAK2JAK1GPR119PDK1 | |
| SCHEMBL18452966 | 0.89 | JAK2 (0.53) | CCR5JAK2JAK1GPR119PDK1 | |
| SCHEMBL1991997 | 0.88 | JAK2 (0.54) | CCR5JAK2JAK1GPR119PDK1 | |
| SCHEMBL31288285 | 0.88 | JAK2 (0.54) | CCR5JAK2JAK1GPR119PDK1 | |
| SCHEMBL2408750 | 0.88 | SMN1; SMN2 (0.52) | CCR5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2408749 | 0.88 | SMN1; SMN2 (0.52) | CCR5NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0871628-A1 | QUINOLIZINONE TYPE COMPOUNDS | Abbott Laboratories (US) | 1998-10-21 | — | — | EP | disclosed |
| US-5599816-A | BACTERICIDE | ABBOTT LABORATORIES (US) | 1997-02-04 | — | — | US | disclosed |
| WO-1996039407-A1 | QUINOLIZINONE TYPE COMPOUNDS | ABBOTT LABORATORIES (US) | 1996-12-12 | — | — | WO | disclosed |