SCHEMBL85695

SCHEMBL85695

COC(=O)[C@@H]1C[C@H](O)CN1C(=O)OC(C)(C)C

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 5/20 0.53
CYP1A2 P05177 1/20 0.53
POLB P06746 1/20 0.53
CYP2C19 P33261 1/20 0.53
ALDH1A1 P00352 1/20 0.52
MMP2 P08253 3/20 0.46
ANPEP P15144 3/20 0.46
CHRM2 P08172 1/20 0.44
CHRM1 P11229 1/20 0.44
CHRM3 P20309 1/20 0.44
NR1H2 P55055 2/20 0.41
NR1H3 Q13133 1/20 0.41
PTPN1 P18031 1/20 0.41
ATM Q13315 1/20 0.40
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
MAPT P10636 2/20 0.39
HTRA1 Q92743 1/20 0.38
P2RX3 P56373 1/20 0.36
KDM4E B2RXH2 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28027805 1.00 CYP3A4 (0.53) CYP3A4CYP1A2POLBCYP2C19ALDH1A1
SCHEMBL1257236 1.00 CYP3A4 (0.53) CYP3A4CYP1A2POLBCYP2C19ALDH1A1
SCHEMBL475537 1.00 CYP3A4 (0.53) CYP3A4CYP1A2POLBCYP2C19ALDH1A1
SCHEMBL85067 1.00 CYP3A4 (0.53) CYP3A4CYP1A2POLBCYP2C19ALDH1A1
SCHEMBL1412106 1.00 CYP3A4 (0.53) CYP3A4CYP1A2POLBCYP2C19ALDH1A1
SCHEMBL5408514 1.00 CYP3A4 (0.53) CYP3A4CYP1A2POLBCYP2C19ALDH1A1
SCHEMBL84794 1.00 CYP3A4 (0.53) CYP3A4CYP1A2POLBCYP2C19ALDH1A1
SCHEMBL3789795 1.00 CYP3A4 (0.53) CYP3A4CYP1A2POLBCYP2C19ALDH1A1
SCHEMBL611185 1.00 CYP3A4 (0.53) CYP3A4CYP1A2POLBCYP2C19ALDH1A1
SCHEMBL3188827 0.90 CYP1A2 (0.52) CYP3A4CYP1A2POLBCYP2C19ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 969 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119350211-A Preparation method of N-Boc-cis-4-hydroxy-L-proline methyl ester 南京安伦化工科技有限公司 2025-01-24 CN claimed
WO-2024103319-A1 METHOD FOR SYNTHESIZING METHYL (1R,2S,5S)-6,6-DIMETHYL-3-AZABICYCLO[3,1,0]HEXYL-2-CARBOXYLATE HYDROCHLORIDE 广东莱佛士制药技术有限公司 2024-05-23 WO claimed
CN-118047713-A Method for synthesizing boceprevir intermediate 广东莱佛士制药技术有限公司 2024-05-17 CN claimed
CN-112194606-A Synthesis process of N-BOC-cis-4-hydroxyproline methyl ester 南京诺希生物科技有限公司 2021-01-08 CN claimed
EP-4747260-A1 MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE F. Hoffmann-La Roche AG (CH) 2026-05-27 EP disclosed
US-12630566-B2 KRas G12D inhibitors Mirati Therapeutics, Inc. (US) 2026-05-19 US disclosed
US-20260070927-A1 INDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE HOFFMANN-LA ROCHE INC. (US) 2026-03-12 US disclosed
EP-4705302-A1 PYRIDO[4,3-D]PYRIMIDINE DERIVATIVES AS MUTANT KRAS G12C INHIBITORS FOR THE TREATMENT OF CANCER Frontier Medicines Corporation (US) 2026-03-11 EP disclosed
EP-4678238-A2 ARGINASE INHIBITORS AND METHODS OF USE THEREOF Astrazeneca AB (SE) 2026-01-14 EP disclosed
US-20260001846-A1 SPIROCYCLOHEXANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS ANTI-APOPTOTIC INHIBITORS SERVIER LAB (FR) 2026-01-01 US disclosed
WO-2025262433-A1 N-CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS MISSION THERAPEUTICS LIMITED (GB) 2025-12-26 WO disclosed
EP-4655073-A2 CEREBLON-BASED KRAS DEGRADING PROTACS ANS USES RELATED THERETO Arvinas Operations, Inc. (US) 2025-12-03 EP disclosed
US-5317016-A Pyrrolidylthiocarbapenem derivative SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) 1994-05-31 US disclosed
US-5264453-A Pyrrolidine derivatives FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1993-11-23 US disclosed
EP-0289911-B1 PYRROLIDINE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1993-06-16 EP disclosed
EP-0528678-A1 A pyrrolidylthiocarbapenem derivative SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) 1993-02-24 EP disclosed
US-5130323-A PYRROLIDINE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1992-07-14 US disclosed
EP-0367130-A2 Pyrrolidine derivatives FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1990-05-09 EP disclosed
US-4916152-A THROMBOXANE A2 ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1990-04-10 US disclosed
EP-0289911-A2 Pyrrolidine derivatives FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1988-11-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12630566-B2 KRas G12D inhibitors KRAS, NRAS, HRAS CYP3A4 4044/4885CYP1A2 4159/4885POLB 2333/4885
US-20260001846-A1 SPIROCYCLOHEXANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS ANTI-APOPTOTIC INHIBITORS BCL2, BCL2A1, BAX CYP3A4 1904/4885CYP1A2 2158/4885POLB 1533/4885
US-20260070927-A1 INDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE MALT1, CCR1, CCR6 CYP3A4 1344/4885CYP1A2 449/4885POLB 2943/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.