Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 12/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14424655 | 0.88 | GNRHR (0.69) | GNRHR | |
| SCHEMBL6976457 | 0.85 | GNRHR (0.49) | GNRHR | |
| SCHEMBL6804909 | 0.85 | GNRHR (0.50) | GNRHR | |
| SCHEMBL7855390 | 0.83 | GNRHR (0.57) | GNRHR | |
| SCHEMBL7855392 | 0.83 | GNRHR (0.57) | GNRHR | |
| SCHEMBL5753476 | 0.82 | GNRHR (0.69) | GNRHR | |
| SCHEMBL14424652 | 0.82 | GNRHR (0.61) | GNRHR | |
| SCHEMBL14438150 | 0.82 | GNRHR (0.57) | GNRHR | |
| SCHEMBL5789796 | 0.81 | GNRHR (0.81) | GNRHR | |
| SCHEMBL14438214 | 0.81 | GNRHR (0.67) | GNRHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449489-B2 | Indolylalkylamino-methylidenecarbamate derivatives useful as GnRH antagonists | ASTRAZENECA AB (SE) | 2008-11-11 | — | — | US | disclosed |
| US-7256188-B2 | 3-aminoalkyl-2-aryl-indole derivatives and their use as GnRH antagonists | ASTRAZENECA AB (SE) | 2007-08-14 | — | — | US | disclosed |
| US-7256188-B2 | 3-aminoalkyl-2-aryl-indole derivatives and their use as GnRH antagonists | ASTRAZENECA AB (SE) | 2007-08-14 | — | — | US | disclosed |
| US-5849764-A | Antagonists of gonadotropin releasing hormone | MERCK & CO., INC. (US) | 1998-12-15 | — | — | US | disclosed |
| EP-0871624-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | Merck & Co., Inc. (US) | 1998-10-21 | — | — | EP | disclosed |
| WO-1997021703-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 1997-06-19 | — | — | WO | disclosed |