SCHEMBL8569701

SCHEMBL8569701

Cc1c(N2CC3CC3(NC(=O)OC(C)(C)C)C2)c(F)cn2c(=O)c(C(=O)O)cc(C3CC3)c12

nearest known ligand 0.36

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
SCN5A Q14524 1/20 0.36
KCNH2 Q12809 3/20 0.32
DPP8 Q6V1X1 1/20 0.32
DPP9 Q86TI2 1/20 0.32
NAMPT P43490 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8575877 0.82 SCN5A (0.36) SCN5AKCNH2
SCHEMBL7506081 0.81 SCN5A (0.38) SCN5AKCNH2
SCHEMBL7501829 0.81 SCN5A (0.38) SCN5AKCNH2
SCHEMBL8563509 0.80 SCN5A (0.47) SCN5AKCNH2
SCHEMBL8571984 0.80 SCN5A (0.39) SCN5AKCNH2
Hydrochloric Acid SCHEMBL8892627 0.80 SCN5A (0.46) SCN5AKCNH2
SCHEMBL14497198 0.79 ACACB (0.39) SCN5AKCNH2
SCHEMBL6795087 0.77 KCNH2 (0.36) SCN5AKCNH2
SCHEMBL6795089 0.77 KCNH2 (0.36) SCN5AKCNH2
SCHEMBL6795091 0.77 KCNH2 (0.36) SCN5AKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0871628-A1 QUINOLIZINONE TYPE COMPOUNDS Abbott Laboratories (US) 1998-10-21 EP disclosed
US-5599816-A BACTERICIDE ABBOTT LABORATORIES (US) 1997-02-04 US disclosed
WO-1996039407-A1 QUINOLIZINONE TYPE COMPOUNDS ABBOTT LABORATORIES (US) 1996-12-12 WO disclosed