Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30963686 | 0.79 | KDM4E (0.54) | ALDH1A1KDM4EHSD17B10GAAHPGD | |
| SCHEMBL7401135 | 0.79 | HAVCR2 (0.34) | MEN1KMT2AMAPK14PTPN1PIM1 | |
| SCHEMBL2460831 | 0.77 | FGFR1 (0.36) | MEN1KMT2AGRM2HAVCR2LCK | |
| SCHEMBL4146649 | 0.76 | ALDH1A1 (0.51) | ALDH1A1KDM4EHSD17B10GAAHPGD | |
| SCHEMBL7403844 | 0.75 | ALDH1A1 (0.41) | ALDH1A1KDM4EHSD17B10GAAHPGD | |
| SCHEMBL1079672 | 0.75 | LCK (0.36) | MAPK1GRM2HAVCR2SMN1; SMN2LCK | |
| SCHEMBL1312899 | 0.74 | KDM4E (0.49) | ALDH1A1KDM4EHSD17B10GAAHPGD | |
| SCHEMBL8569567 | 0.73 | KDM4E (0.47) | ALDH1A1KDM4EHSD17B10GAAHPGD | |
| SCHEMBL8565559 | 0.72 | DRD4 (0.45) | ALDH1A1KDM4EHSD17B10GAAHPGD | |
| SCHEMBL29126966 | 0.72 | ALDH1A1 (0.59) | ALDH1A1KDM4EHSD17B10GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623620-B1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR (FR) | 1998-09-09 | — | — | EP | disclosed |
| US-5599812-A | ANTISEROTONINE AGENTS | ADIR ET COMPAGNIE (FR) | 1997-02-04 | — | — | US | disclosed |
| EP-0623620-A1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR ET COMPAGNIE (FR) | 1994-11-09 | — | — | EP | disclosed |