Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.42 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 4/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HSPH1 | Q92598 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL857026 | 0.82 | LRRK2 (0.46) | LRRK2SYKEGFR | |
| SCHEMBL857689 | 0.82 | PRKCI (0.53) | LRRK2SYKEGFR | |
| SCHEMBL857093 | 0.80 | PPARG (0.49) | PKMLRRK2SYKCYP2C9 | |
| SCHEMBL1362011 | 0.79 | PIM2 (0.46) | PKMLRRK2SYKEGFR | |
| SCHEMBL1362007 | 0.79 | PIM2 (0.46) | PKMLRRK2SYKEGFR | |
| SCHEMBL878789 | 0.79 | EGFR (0.49) | LRRK2SYKCYP3A4CYP2C9EGFR | |
| SCHEMBL859126 | 0.79 | CAMKK2 (0.46) | LRRK2CYP3A4CYP2C9 | |
| SCHEMBL857947 | 0.77 | CHUK (0.49) | LRRK2CYP3A4CYP2C9EGFR | |
| SCHEMBL857622 | 0.75 | MAP4K4 (0.63) | LRRK2SYK | |
| SCHEMBL858550 | 0.72 | BTK (0.52) | LRRK2SYKCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143271-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143271-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2012-03-27 | — | — | US | disclosed |